Mutation Induction in Cultured Human Cells after Low-dose and Low-dose-rate γ-ray Irradiation: Detection by LOH Analysis
نویسندگان
چکیده
منابع مشابه
Low dose hypersensitivity after high-LET irradiation
An unexpected hypersensitivity has been reported for several cell lines at low doses (<1Gy), which is not consistent with the linear-quadratic approach currently used in general for the description of survival curves [1,2,3,4]. The corresponding substructure of the survival curves has been attributed to induced radioresistance. There are indications, that high-LET irradiation with neutron or pi...
متن کاملCharacterizing low dose and dose rate effects in rodent and human neural stem cells exposed to proton and gamma irradiation☆
Past work has shown that exposure to gamma rays and protons elicit a persistent oxidative stress in rodent and human neural stem cells (hNSCs). We have now adapted these studies to more realistic exposure scenarios in space, using lower doses and dose rates of these radiation modalities, to further elucidate the role of radiation-induced oxidative stress in these cells. Rodent neural stem and p...
متن کاملEffects of N-acetylcysteine on life shortening induced by chronic low dose-rate gamma-ray exposure in mice
Background: The development of methods to alleviate radiation-induced health effects is important for the practical use of radiation therapy and for understanding the molecular mechanisms mediating these effects. Here, we examined the protective capability of N-acetylcysteine (NAC) on life-shortening effects induced by continuous low dose-rate gamma-ray exposure in mice. Materials and Methods: ...
متن کاملInduction of radioresistant nasopharyngeal carcinoma cell line CNE-2R by repeated high-dose X-ray irradiation
Background: All To enhance the curative effect of radiotherapy, we established a radio-resistant cell line, CNE-2R from CNE-2, a radio-sensitive type of CNE, through repeated irradiation. The developed cell line provides a basis for further studies on the radio-resistance of CNE and the molecular mechanism of radiotherapy sensitization drugs. Materials and Methods: The CNE-2 cell line was selec...
متن کاملIncreased γ-H2A.X Intensity in Response to Chronic Medium-Dose-Rate γ-Ray Irradiation
BACKGROUND The molecular mechanisms of DNA repair following chronic medium-dose-rate (MDR) γ-ray-induced damage remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS We used a cell function imager to quantitatively measure the fluorescence intensity of γ-H2A.X foci in MDR (0.015 Gy/h and 0.06 Gy/h) or high-dose-rate (HDR) (54 Gy/h) γ-ray irradiated embryonic fibroblasts derived from DNA-depe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2007
ISSN: 0449-3060,1349-9157
DOI: 10.1269/jrr.06054